Beruflicher Werdegang
April 2018 Habilitation auf dem Gebiet der experimentellen Virologie,
Universitätsklinikum Leipzig
2002-2007 Promotion zum Dr. rer. nat. an der Universität Leipzig
2005-2006 Gastwissenschaftlerin, Georgia State University, Atlanta, USA
1999-2000 Kurse als non-graduating student, Queen's University of Belfast, UK
1996-2002 Biologiestudium, Martin-Luther Universität Halle-Wittenberg
Berufliche Aktivitäten
2014-2017 Co-Chair des Arbeitskreises "Zellbiologie der Virusinfektion" der
Gesellschaft für Virologie
Eingeworbene
Forschungsmittel
2014 DFG Förderung (CL 459/3-1)
2014 Forschungsförderung durch die Roland Ernst Stiftung
2009 Forschungsförderung durch die medizinische Fakultät im Rahmen des
Nachwuchsförderprogrammes formel.1
Akademische Auszeichnungen
2015 Reisestipendium 6th World Congress on Targeting Mitochondria,
Berlin
2012 Posterpreis, 10. Research Festival of Life Sciences, Leipzig
2006 Reisestipendium, Treffen der amerikanischen Gesellschaft für
Virologie, Madison, USA
2000 Shirodaria prize für die beste Abschlussnote im Fach Virologie an der
Queen´s University of Belfast
Mitgliedschaften
European Bioinformatics Center (EVBC), Gesellschaft
für Virologie
(GfV), Deutscher Hochschulverband (DHV)
Publikationsliste
2023
Schulz J, Schilling E, Fabian C, Zenclussen AC, Stojanovska V, Claus C.
Dissecting Rubella Placental Infection in an In Vitro Trophoblast Model.
International Journal of Molecular Sciences. 2023; 24(9):7894. doi.org/10.3390/ijms24097894
Henschke V, Hild K, Schilling E, Haas J, Filipova V, Erbe S, König R,
Hübschen JM, Laufs U, Claus C*, Boeckel JN*. Rubella virus infection in
endothelial cells reduces angiogenesis via interferon beta-induced CXCL10.
*Shared authorship
Jung M, Hartmann C, Ehrhardt T, Peter LM, Abid CL, Harwardt B, Hirschfeld J,
Claus C, Haferkamp U, Pless O, Nastainczyk-Wulf M, Kehlen A, Schlote D, Schroder
IS, Rujescu D. Generation of a set of induced pluripotent stem cell lines from
two Alzheimer disease patients carrying APOE4 (MLUi007-J; MLUi008-A) and healthy
old donors carrying APOE3 (MLUi009-A; MLUi010-B) to study APOE in aging and
2022
Wald ME, Claus C, Konrath A, Nieper H, Muluneh A, Schmidt V, Vahlenkamp TW,
Hufsky F, Abecasis A, Agudelo-Romero P, Bletsa M, Brown K, Claus C,
Deinhardt-Emmer S, Deng L, Friedel CC, Gismondi MI, Kostaki EG, Kühnert D,
Kulkarni-Kale U, Metzner KJ, Meyer IM, Miozzi L, Nishimura L, Paraskevopoulou S,
Pérez-Cataluña A, Rahlff J, Thomson E, Tumescheit C, van der Hoek L, Van Espen
L, Vandamme AM, Zaheri M, Zuckerman N, Marz M. Women in the European Virus
Schilling E, Wald ME, Schulz J, Werner LE, Claus C. Interferon Signaling-
Dependent Contribution of Glycolysis to Rubella Virus Infection.
Pathogens. 2022;11(5):537. doi: 10.3390/pathogens11050537.
Schilling E, Pfeiffer L, Hauschildt S, Koehl U, Claus C. CD14 Is Involved in the Interferon Response of Human Macrophages to Rubella Virus Infection. Biomedicines. 2022; 10(2):266. doi: 10.3390/biomedicines10020266.
Wald ME, Sieg M, Schilling E, Binder M, Vahlenkamp TW, Claus C. The Interferon Response Dampens the Usutu Virus Infection-Associated Increase in Glycolysis. Front Cell Infect Microbiol. 2022; 12:823181. doi: 10.3389/fcimb.2022.823181.
2021
Schilling E, Grahnert A, Pfeiffer L, Koehl U, Claus C*,
Hauschildt S*. The Impact of Rubella Virus Infection on a Secondary InflammatoryResponse in Polarized Human Macrophages. Front Immunol. 2021; v12:772595. doi:
10.3389/fimmu.2021.772595
*Shared authorship
Claus C*, Fritz R*, Schilling E, Reibetanz U, The Metabolic Response of Various Cell Lines to Microtubule-Driven Uptake of Lipid- and Polymer-Coated Layer-by-Layer Microcarriers. Pharmaceutics 2021, 13, 1441. https://doi.org/10.3390/pharmaceutics13091441
*shared first author
Böhnke J, Pinkert S, Schmidt M, Binder H, Bilz NC, Jung M, Reibetanz U, Beling A, Rujescu D, Claus C. Coxsackievirus B3 Infection of Human iPSC Lines and Derived Primary Germ-Layer Cells Regarding Receptor Expression. Int J Mol Sci. 2021 Jan 27;22(3):1220. doi: 10.3390/ijms22031220
2020
Claus C, Jung M, Hübschen JM. Pluripotent stem cell-based models: a peephole into virus infections during early pregnancy. Cells. 2020, 9, 542.
Scheffler K, Bilz NC, Brueckner M, Stanifer ML, Boulant S, Claus C*, Reibetanz U*. Enhanced uptake and endosomal release of LbL microcarriers functionalized with reversible fusion proteins. ACS Appl. Bio Mater. 2020, xxxx, xxx. doi.org/10.1021/acsabm.9b01168
*Shared authorship
2019
Bilz NC*, Willscher E*, Binder H, Böhnke J, Stanifer ML, Hübner D, Boulant S, Liebert UG, Claus C. Teratogenic rubella virus alters the endodermal differentiation capacity of human induced pluripotent stem cells. Cells. 2019; 8(8). pii: E870. doi: 10.3390/cells8080870.
*Shared authorship
2018
Zobel S*, Lorenz M*, Frascaroli G, Böhnke J, Bilz NC, Stanifer ML, Boulant S, Bergs S, Liebert UG, Claus C. Rubella virus strain-associated differences in the induction of oxidative stress are independent of their interferon activation. Viruses. 2018; 10(10). pii: E540. doi: 10.3390/v10100540
Kräter M*, Sapudom J*, Bilz NC, Pompe T, Guck J, Claus C. Alterations in cell mechanics by actin cytoskeletal changes correlate with strain-specific rubella virus phenotypes for cell migration and induction of apoptosis. Cells. 2018; 7(9). pii: E136. doi: 10.3390/cells7090136. *Shared authorshipScheffler K, Claus C, Stanifer ML, Boulant S, Reibetanz U. Reversible fusion proteins as a tool to enhance uptake of virus-functionalized LbL microcarriers. Biomacromolecules. 2018; 19(8):3212-3223. doi: 10.1021/acs.biomac.8b00360. Bilz NC*, Jahn K*, Lorenz M, Lüdtke A, Hübschen JM, Geyer H, Mankertz A, Hübner D, Liebert UG, Claus C. Rubella viruses shift cellular bioenergetics to a more oxidative and glycolytic phenotype with a strain-specific requirement for glutamine. J Virol. 2018; 92(17). pii: e00934-18. doi:10.1128/JVI.00934-18. *Shared authorship
2017
Hübner D, Jahn K, Pinkert S, Böhnke J, Jung M, Fechner H, Rujescu D, Liebert UG, Claus C. Infection of iPSC Lines with Miscarriage-Associated Coxsackievirus and Measles Virus and Teratogenic Rubella Virus as a Model for Viral Impairment of Early Human Embryogenesis. ACS Infect Dis. 2017; 3(12):886-897. doi: 10.1021/acsinfecdis.7b00103.
Claus C, Bergs S, Emmrich NC, Hübschen JM, Mankertz A, Liebert UG. A sensitive one-step TaqMan amplification approach for detection of rubella virus clade I and II genotypes in clinical samples. Arch Virol. 2017;162(2):477-486. doi:10.1007/s00705-016-3131-1. 2016Reibetanz U, Hübner D, Jung M, Liebert UG, Claus C. Influence of growth characteristics of induced pluripotent stem cells on their uptake efficiency for Layer-by-Layer microcarriers. ACS Nano. 2016;10(7):6563-73. doi:10.1021/acsnano.6b00999. Geyer H, Bauer M, Neumann J, Lüdde A, Rennert P, Friedrich N, Claus C, Perelygina L, Mankertz A. Gene expression profiling of rubella virus infected primary endothelial cells of fetal and adult origin. Virol J. 2016;13:21. doi: 10.1186/s12985-016-0475-9. 2015Claus C*, Manssen L*, Hübner D, Roßmark S, Bothe V, Petzold A, Große C, Reins M, Mankertz A, Frey TK, Liebert UG. Activation of the mitochondrial apoptotic signaling platform during rubella virus infection. Viruses. 2015;7(12):6108-26. doi: 10.3390/v7122928. *Shared authorshipFichtner M, Claus C, Lessig-Owlanj J, Arnhold J, Reibetanz U. The application of LbL-microcarriers for the treatment of chronic inflammation: monitoring the impact of LbL-microcarriers on cell viability. Macromol Biosci. 2015;15(4):546-57. doi: 10.1002/mabi.201400405. 2014Milbradt J, Kraut A, Hutterer C, Sonntag E, Schmeiser C, Ferro M, Wagner S, Lenac T, Claus C, Pinkert S, Hamilton ST, Rawlinson WD, Sticht H, Couté Y, Marschall M. Proteomic analysis of the multimeric nuclear egress complex of human cytomegalovirus. Mol Cell Proteomics. 2014;13(8):2132-46. doi:10.1074/mcp.M113.035782. Claus C, Liebert UG. A renewed focus on the interplay between viruses and mitochondrial metabolism. Arch Virol. 2014;159(6):1267-77. doi:10.1007/s00705-013-1841-1. 2013Claus C, Schönefeld K, Hübner D, Chey S, Reibetanz U, Liebert UG. Activity increase in respiratory chain complexes by rubella virus with marginal induction of oxidative stress. J Virol. 2013;87(15):8481-92. doi: 10.1128/JVI.00533-13.2012Claus C, Tzeng WP, Liebert UG, Frey TK. Rubella virus-like replicon particles: analysis of encapsidation determinants and non-structural roles of capsid protein in early post-entry replication. J Gen Virol. 2012;93(Pt3):516-25. doi: 10.1099/vir.0.038984-0. 2011Claus C, Chey S, Heinrich S, Reins M, Richardt B, Pinkert S, Fechner H, Gaunitz F, Schäfer I, Seibel P, Liebert UG. Involvement of p32 and microtubules in alteration of mitochondrial functions by rubella virus. J Virol. 2011;85(8):3881-92. doi: 10.1128/JVI.02492-10. Chey S, Claus C, Liebert UG. Improved method
for simultaneous isolation of proteins and nucleic acids. Anal Biochem. 2011;411(1):164-6.
doi:10.1016/j.ab.2010.11.020. 2010Chey S*, Claus C*, Liebert UG. Validation and application of normalization factors for gene expression studies in rubella virus-infected cell lines with quantitative real-time PCR. J Cell Biochem. 2010; 110(1):118-28. doi:10.1002/jcb.22518. *Shared authorship2007Claus C, Tzeng WP, Liebert UG, Frey TK. Rubella virus-induced superinfection exclusion studied in cells with persisting replicons. J Gen Virol. 2007;88(Pt10):2769-73. Claus C, Tzeng WP, Liebert UG, Frey TK. Analysis of the selective advantage conferred by a C-E1 fusion protein synthesized by rubella virus DI RNAs. Virology. 2007;369(1):19-34. 2006Claus C, Hofmann J, Uberla K, Liebert UG. Rubella virus pseudotypes and a cell-cell fusion assay as tools for functional analysis of the rubella virus E2 and E1 envelope glycoproteins. J Gen Virol. 2006; 87(Pt 10):3029-37. Reibetanz U, Claus C, Typlt E, Hofmann J, Donath E. Defoliation and plasmid delivery with layer-by-layer coated colloids. Macromol Biosci. 2006;6(2):153-60. 
