You are here: Skip Navigation LinksPaul Flechsig Institute – Centre of Neuropathology and Brain Research Researchgroups Group Roßner: Protein Aggregation Disorders

Group Prof. Dr. Steffen Roßner

​​​​Our group is driven by the curiosity to identify molecular and cellular mechanisms of post-translational protein modifications in neurodegenerative and protein aggregation disorders that have a neuroinflammatory component. Special focus is given on protein aggregation in Alzheimer's and Parkinson’s disease and on neuroinflammation in stroke. These clinical conditions share glutaminyl cyclase-catalyzed pyroglutamate modification of aggregation-prone and/or pro-inflammatory proteins and its reversal by antagonizing enzymes. This provides a basis for pharmacological interference with pathological pathways characteristic for these clinical entities. We combine cellular and pre-clinical experimental models with the analyses of human brain tissue from the respective clinical conditions.​

​For more informations: rossnerlab​

Signatures of modified Abeta peptides in brains of Alzheimer's disease subjects revealed by novel monoclonal antibodies

Enzymatic regulation of CCL2 bioactivity in neuroinflammation

Contributions of glutaminyl cyclases to the pathogenesis of neurodegenerative disorders

Are alpha-Synuclein fragments new substrates of glutaminyl cyclase?

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