Our research interests

​The aim of our group is to better understand the function of the brain, focussing in particular on the function, plasticity and metabolism of presynaptic nerve terminals. We conduct studies at different levels, from single molecules to neuronal networks. To this end, we develop new electrophysiological, optical, genetic and computational technologies that improve spatial and temporal resolution. We carry out basic research, driven by the curiosity to decipher previously inaccessible processes. In addition, we conduct applied neuroscientific research to improve therapeutic options for neurological diseases.

Our research is funded by the European Research Council (ERC) and the German Research Foundation (DFG).​​

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Flagge der EU und Logo des European Research Council

carl-ludwig-institut-logo-synabs.png DFG FO​​R 3004

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Selected recent publications

Bullmann T, Kaas T, Ritzau-Jost A, Wöhner A, Kirmann T, Rizalar FS, Holzer M, Nerlich J, Puchkov D, Geis C, Eilers J, Kittel RJ, Arendt T, Haucke V, Hallermann S (2024): Human iPSC-derived neurons with reliable synapses and large presynaptic action potenti​​als. J Neurosci ​44:e0971232024

Weichard I, Taschenberger H, Gsell F, Bornschein G, Ritzau-Jost A, Schmidt H, Kittel RJ, Eilers J, Neher E, Hallermann S, Nerlich J (2023): Fully-primed slowly-recovering vesicles mediate presynaptic LTP at neocortical neurons. PNAS 120:e2305460120

Steinke S, Kirmann T, Loi EA, Nerlich J, Weichard I, Kuhn P, Bullmann T, Ritzau-Jost A, Rizalar FS, Prüss H, Haucke V, Geis C, Hust M, Hallermann S (2023): NMDA-receptor-Fc-fusion constructs neutralize anti-NMDA receptor antibodies. Brain 146:1812-1820

Liu C, Cai X, Ritzau-Jost A, Kramer PF, Li Y, Khaliq ZM, Hallermann S, Kaeser P (2022): An action potential initiation mechanism in distal axons for the control of dopamine release. Science 375:1378-1385​​

​Ritzau-Jost A, Tsintsadze T, Krueger M, Ader J, Bechmann I, Eilers J, Barbour B, Smith SM, Hallermann S (2021): Large, stable spikes exhibit differential broadening in excitatory and inhibitory neocortical boutons. Cell Rep 34:108612

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