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Publications

2018

  • ​Oakey LA, Fletcher RS, Elhassan YS, Cartwright DM, Doig CL, Garten A, Thakker A, Maddocks ODK, Zhang T, Tennant DA, Ludwig C, Lavery GG. Metabolic tracing reveals novel adaptations to skeletal muscle cell energy production pathways in response to NAD (+) depletion. Wellcome Open Res. 2018;3:147.
  • Sociali G, Grozio A, Caffa I, Schuster S, Becherini P, Damonte P, Sturla L, Fresia C, Passalacqua M, Mazzola F, Raffaelli N, Garten A, Kiess W, Cea M, Nencioni A, Bruzzone S. SIRT6 deacetylase activity regulates NAMPT activity and NAD(P)(H) pools in cancer cells. FASEB J. 2018:fj201800321R.
  • Nurten E, Vogel M, Michael Kapellen T, Richter S, Garten A, Penke M, Schuster  S, Körner A, Kiess W, Kratzsch J. Omentin-1 and NAMPT serum concentrations are higher and CK-18 levels are lower in children and adolescents with type 1 diabetes when compared to healthy age, sex and BMI matched controls. J Pediatr Endocrinol Metab. 2018;31(9):959-969.
  • Grohmann T, Penke M, Petzold-Quinque S, Schuster S, Richter S, Kiess W, Garten A. Inhibition of NAMPT sensitizes MOLT4 leukemia cells for etoposide treatment through the SIRT2-p53 pathway. Leuk Res. 2018;69:39-46.
  • Kässner F, Sauer T, Penke M, Richter S, Landgraf K, Körner A, Kiess W, Händel N, Garten A. Simvastatin induces apoptosis in PTEN‑haploinsufficient lipoma cells. Int J Mol Med. 2018;41(6):3691-3698.
  • Dall M, Penke M, Sulek K, Matz-Soja M, Holst B, Garten A, Kiess W, Treebak JT. Hepatic NAD(+) levels and NAMPT abundance are unaffected during prolonged high-fat diet consumption in C57BL/6JBomTac mice. Mol Cell Endocrinol. 2018;473:245-256.

2017

  • Penke M, Schuster S, Gorski T, Gebhardt R, Kiess W, Garten A. Oleate ameliorates palmitate-induced reduction of NAMPT activity and NAD levels in primary human hepatocytes and hepatocarcinoma cells. Lipids Health Dis. 2017;16(1):191.
  • Garten A, Schuster S, Penke M: Could NAMPT inhibition become a potential treatment option in hepatocellular carcinoma? Expert Rev Anticancer Ther. 2017;17(4):289-291.
  • Landgraf K, Schuster S, Meusel A, Garten A, Riemer T, Schleinitz D, Kiess W, Körner A: Short-term overfeeding of zebrafish with normal or high-fat diet as a model for the development of metabolically healthy versus unhealthy obesity. BMC Physiol. 2017;17(1):4
  • Lede V, Meusel A, Garten A, Popkova Y, Penke M, Franke C, Ricken A, Schulz A, Kiess W, Huster D, Schöneberg T, Schiller J: Altered hepatic lipid metabolism in mice lacking both the melanocortin type 4 receptor and low density lipoprotein receptor. PLoS One. 2017;12(2):e0172000
  • Fletcher RS, Ratajczak J, Doig CL, Oakey LA, Callingham R, Da Silva Xavier G,  Garten A, Elhassan YS, Redpath P, Migaud ME, Philp A, Brenner C, Canto C, Lavery  GG. Nicotinamide riboside kinases display redundancy in mediating nicotinamide mononucleotide and nicotinamide riboside metabolism in skeletal muscle cells. Mol Metab. 2017;6(8):819-832.
  • Mutz CN, Schwentner R, Aryee DNT, Bouchard EDJ, Mejia EM, Hatch GM, Kauer MO, Katschnig AM, Ban J, Garten A, Alonso J, Banerji V, Kovar H. EWS-FLI1 confers exquisite sensitivity to NAMPT inhibition in Ewing sarcoma cells. Oncotarget. 2017;8(15):24679-24693.

2016

  • Riammer S, Garten A, Schaab M, Grunewald S, Kiess W, Kratzsch J, Paasch U: Nicotinamide phosphoribosyltransferase production in human spermatozoa is influenced by maturation stage. Andrology. 2016;4(6):1045-1053.
  • Leipert J, Kässner F, Schuster S, Händel N, Körner A, Kiess W, Garten A: Resveratrol potentiates growth inhibitory effects of rapamycin in PTEN-deficient lipoma cells by suppressing p70S6 kinase activity. Nutr Cancer. 2016; 4:1-8.

2015

  • ​Garten A, Schuster S, Penke M, Gorski T, de Giorgis T, Kiess W: Physiological and pathophysiological roles of NAMPT and NAD metabolism. Nat Rev Endocrinol. 2015;11(9):535-46.
  • Penke M, Larsen PS, Schuster S, Dall M, Jensen BA, Gorski T, Meusel A, Richter S, Vienberg SG, Treebak JT, Kiess W, Garten A: Hepatic NAD salvage pathway is enhanced in mice on a high-fat diet. Mol Cell Endocrinol. 2015;412:65-72.
  • Wilhelm F, Kässner F, Schmid G, Kratzsch J, Laner A, Wabitsch M, Körner A, Kiess W, Garten A: Phosphatidylinositol 3-kinase (PI3K) signalling regulates insulin-like-growth factor binding protein-2 (IGFBP-2) production in human adipocytes. Growth Horm IGF Res. 2015;25(3):115-20.
  • Schuster S, Penke M, Gorski T, Gebhardt R, Weiss TS, Kiess W, Garten A: FK866-induced NAMPT inhibition activates AMPK and downregulates mTOR signaling in hepatocarcinoma cells. Biochem Biophys Res Commun. 2015;458(2):334-40.

2014

  • Schuster S, Penke M, Gorski T, Petzold-Quinque S, Damm G, Gebhardt R, Kiess W, Garten A: Resveratrol differentially regulates NAMPT and SIRT1 in hepatocarcinoma cells and primary human hepatocytes. PLoS One. 2014;9(3):e91045.
  • Schmid GL, Kassner F, Uhlig HH, Korner A, Kratzsch J, Handel N, Zepp F, Kowalzik F, Laner A, Starke S, Wilhelm FK, Schuster S, Viehweger A, Hirsch W, Kiess W, Garten A: Sirolimus treatment of severe PTEN hamartoma tumor syndrome: case report and in vitro studies. Pediatr Res  2014;75(4):527-34. 

2013

  • ​Christensen MK, Erichsen KD, Olesen UH, Tjornelund J, Fristrup P, Thougaard A, Nielsen SJ, Sehested M, Jensen PB, Loza E, Kalvinsh I, Garten A, Kiess W, Bjorkling F:Nicotinamide phosphoribosyltransferase inhibitors, design, preparation, and structure-activity relationship. J Med Chem 2013, 56(22):9071-88.
  • Sommerweiss D, Gorski T, Richter S, Garten A, Kiess W: Oleate rescues INS-1E beta-cells from palmitate-induced apoptosis by preventing activation of the unfolded protein response. Biochem Biophys Res Commun 2013, 441(4):770-6.
  • Spinnler R, Gorski T, Stolz K, Schuster S, Garten A, Beck-Sickinger AG, Engelse MA, Koning EJP de, Korner A, Kiess W, Maedler K: The adipocytokine Nampt and its product NMN have no effect on beta-cell survival but potentiate glucose stimulated insulin secretion. PLoS One. 2013, 8(1):e54106.

Earlier

  • ​Garten A, Schuster S, Kiess W: The insulin-like growth factors in adipogenesis and obesity. Endocrinol Metab Clin North Am 2012, 41(2):283-95, v-vi.
  • Friebe D, Neef M, Kratzsch J, Erbs S, Dittrich K, Garten A, Petzold-Quinque S, Bluher S, Reinehr T, Stumvoll M, Bluher M, Kiess W, Korner A: Leucocytes are a major source of circulating nicotinamide phosphoribosyltransferase (NAMPT)/pre-B cell colony (PBEF)/visfatin linking obesity and inflammation in humans. Diabetologia 2011, 54(5):1200-11.
  • Garten A, Petzold S, Schuster S, Korner A, Kratzsch J, Kiess W: Nampt and its potential role in inflammation and type 2 diabetes. Handb Exp Pharmacol 2011, (203):147-64.
  • Schuster S, Hechler C, Gebauer C, Kiess W, Kratzsch J: Leptin in maternal serum and breast milk: association with infants' body weight gain in a longitudinal study over 6 months of lactation. Pediatr. Res 2011, 70(6):633-7.
  • Garten A, Petzold S, Barnikol-Oettler A, Korner A, Thasler WE, Kratzsch J, Kiess W, Gebhardt R: Nicotinamide phosphoribosyltransferase (NAMPT/PBEF/visfatin) is constitutively released from human hepatocytes. Biochem Biophys Res Commun 2010, 391(1):376-81.
  • Olesen UH, Petersen JG, Garten A, Kiess W, Yoshino J, Imai S, Christensen MK, Fristrup P, Thougaard AV, Bjorkling F, Jensen PB, Nielsen SJ, Sehested M: Target enzyme mutations are the molecular basis for resistance towards pharmacological inhibition of nicotinamide phosphoribosyltransferase. BMC Cancer 2010, 10:677
  • Vogel R, Garten A, Klammt J, Barnikol-Oettler A, Kiess W: Activation of Erk1/2 phosphorylation but not of Akt/Pkb through an inducible CSF1R/IRR-receptor construct in INS-1E beta-cells. Arch Physiol Biochem 2010, 116(3):128-36.
  • Garten A, Petzold S, Korner A, Imai S, Kiess W: Nampt: linking NAD biology, metabolism and cancer. Trends Endocrinol Metab 2009, 20(3):130-8.
  • Imai S, Kiess W: Therapeutic potential of SIRT1 and NAMPT-mediated NAD biosynthesis in type 2 diabetes. Front Biosci (Landmark Ed) 2009, 14:2983-95.
  • Kiess W, Petzold S, Topfer M, Garten A, Bluher S, Kapellen T, Korner A, Kratzsch J: Adipocytes and adipose tissue. Best Pract Res Clin Endocrinol Metab 2008, 22(1):135-53.
  • Sommer G, Garten A, Petzold S, Beck-Sickinger AG, Bluher M, Stumvoll M, Fasshauer M: Visfatin/PBEF/Nampt: structure, regulation and potential function of a novel adipokine. Clin Sci (Lond) 2008, 115(1):13-23.
  • Korner A, Garten A, Bluher M, Tauscher R, Kratzsch J, Kiess W: Molecular characteristics of serum visfatin and differential detection by immunoassays. J Clin Endocrinol Metab 2007, 92(12):4783-91.
  • Revollo JR, Korner A, Mills KF, Satoh A, Wang T, Garten A, Dasgupta B, Sasaki Y, Wolberger C, Townsend RR, Milbrandt J, Kiess W, Imai S: Nampt/PBEF/Visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme. Cell Metab 2007, 6(5):363-75.
  • Raile K, Klammt J, Garten A, Laue S, Bluher M, Kralisch S, Kloting N, Kiess W: Glucose regulates expression of the nerve growth factor (NGF) receptors TrkA and p75NTR in rat islets and INS-1E beta-cells. Regul Pept 2006, 135(1-2):30-8.
  • Kiess W, Kratzsch J, Keller E, Schneider A, Raile K, Klammt J, Seidel B, Garten A, Schmidt H, Pfaffle R: Clinical examples of disturbed IGF signaling: intrauterine and postnatal growth retardation due to mutations of the insulin-like growth factor I receptor (IGF-IR) gene. Rev Endocr Metab Disord 2005, 6(3):183-7.
  • Klammt J, Garten A, Barnikol-Oettler A, Beck-Sickinger AG, Kiess W: Comparative analysis of the signaling capabilities of the insulin receptor-related receptor. Biochem Biophys Res Commun 2005, 327(2):557-64.
  • Korner A, Bluher S, Kapellen T, Garten A, Klammt J, Kratzsch J, Kiess W: Obesity in childhood and adolescence: a review in the interface between adipocyte physiology and clinical challenges. Hormones (Athens) 2005, 4(4):189-99.
  • Raile K, Klammt J, Laue S, Garten A, Bluher M, Kralisch S, Kloting N, Kiess W: Glucose concentration and AMP-dependent kinase activation regulate expression of insulin receptor family members in rat islets and INS-1E beta cells. Diabetologia 2005, 48(9):1798-809.
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