Protease-signaling in vascular disease and sterile inflammation

• Vascular mechanisms of kidney disease
• Inflammation in the central nervous system
• Coagulation regulators in immunity

Currently the group has several collaborative projects within the Leipzig University and with external institutions.

1. ​Shahzad K, …, Isermann B. Activated protein C reverses epigenetically sustained p66Shc expression in plaque-associated macrophages in diabetes. Commun Biol 2018;1:1-18. doi: 10.1038/s42003-018-0108-5.
2. Madhusudhan T, …, Isermann B. Signal integration at the PI3K-p85-XBP1 hub endows coagulation protease activated protein C with insulin-like function. Blood. 2017; 130(12):1445-1455. doi: 10.1182/blood-2017-02-767921.
3. Ranjan S, …, Isermann B. Activated protein C protects from GvHD via PAR2/PAR3 signalling in regulatory T-cells. Nat Commun 2017;8(1):311. doi: 10.1038/s41467-017-00169-4.
4. Nazir S, …, Isermann B*, Shahzad K*. Cytoprotective activated protein C averts Nlrp3 inflammasome-induced ischemia-reperfusion injury via mTORC1 inhibition. Blood 2017; 130(24):2664-2677. doi: 10.1182/blood-2017-05-782102.
5. Kohli S, …, Isermann B. Maternal extracellular vesicles and platelets promote preeclampsia through inflammasome activation in embryonic trophoblast. Blood 2016;128(17):2153-2164. doi: 10.1182/blood-2016-03-705434

Students interested in completing their thesis or practical work in our research group should please contact Prof. Dr. med. Berend Isermann.