Collaborative Research Center "Mechanisms of Obesity" |
This collaborative research center (Sonderforschungsbereich SFB 1052) is
sponsored by the German Research Foundation "Deutsche Forschungsgemeinschaft" (DFG) and has
started at the beginning of the year 2013 at the Faculty of Medicine at the
University Leipzig. The CRCs speaker is Prof. Dr. Matthias Blüher and the vice
speaker is Prof. Dr. Michael Stumvoll. Further information on the basic research projects of
this CRC can be found on the website of
the SFB 1052. |
Integrated Research and Treatment Center (IFB) AdiposityDiseases |
The IFB AdiposityDiseases is a joint center of the Medical Faculty of the University Leipzig and the University Hospital IFB Plus Symbol Leipzig. It is sponsored by the Federal Ministry of Education and Research. The IFB cooperates with many hospitals and institutes of the University Hospital and the University. Scientific Director of the IFB AdiposityDiseases is Prof. Dr. Michael Stumvoll. Further information |
Privileged Partner on campus: Helmholtz-Institute of Metabolism, Adiposity, and Vascular function (HI-MAG) |
The HI-MAG was founded by the Helmholtz Zentrum
München - German Research Center for
Environmental Health and the University of Leipzig. Its main research focus is
the biology of adipose tissue, energy metabolis, and the effects of vascular
function. Further information Hormones and Health study - in collaboration with Helmholtz-Institute of Metabolism, Adiposity, and Vascular function (HI-MAG)The study aims to characterize five highly interconnected physiological systems in patients undergoing cross-sex hormone therapy - namely glucose and lipid metabolism, energy balance, eating behavior, functional brain networks involved in the regulation of eating behavior and the cardiovascular system - to gain novel insights into the effects of sex hormones on the human body. Gathered information will help to identify pathophysiological mechanisms for the development of overeating/obesity, insulin resistance, and cardiovascular disease. Secondarily, the relationships between the gut and oral microbiomes and metabolomes and circulating bacterial signatures will be investigated in relation to the other pervasive physiological systems. For further information, please refer to clinicaltrials.gov (NCT04838249). Further information Transgender network University Hospital Leipzig The obese taste bud study - in collaboration with Helmholtz-Institute of Metabolism, Adiposity, and Vascular function (HI-MAG)The Obese Taste Bud (OTB) Study is a prospective cohort study at the University of Leipzig Obesity Centre in cooperation with the Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG)- Helmholtz Center Munich at the University Leipzig and the University Clinic Leipzig, investigating taste perception and taste cell homeostasis in obesity. Taste is a potent driver for food preference and contributes to caloric intake and obesity is associated with alterations in taste perception and loss of taste buds. Questionnaire-based information on physical and mental health, eating behavior, physical activity, and dental hygiene are obtained, and biomaterial (saliva, tongue swap, blood, stool) is collected for analysis of e.g. adipokines, inflammatory and microbial agents. Taste bud biopsies and taste bud counts are obtained to unravel mechanisms that implicate taste perception in weight regulation. Further information
|
Whole-room indirect calorimetry at the Helmholtz-Institute of Metabolism, Adiposity, and Vascular function (HI-MAG) and the university clinic leipzigWhole-room indirect calorimetry has recently become available at the Helmholtz Institute for Metabolic, Obesity, and Vascular Research (HI-MAG) and the University Hospital Leipzig. This gold-standard technique allows for precise measurement of energy expenditure in humans. Our research teams aim to integrate this method in order to thoroughly characterize the metabolism of both healthy individuals and patients. The patients undergoing calorimetry will include obese individuals, those with rare diseases, athletes, individuals receiving hormone therapy, as well as children. Further information
Imaging and Curing Environmental Metabolic Diseases (ICEMED) |
The Helmholtz Alliance ICEMED – Imaging and Curing Environmental Metabolic
Diseases – is a network of synergistic excellence representing a worldwide
unique research consortium of biomedical research scientists, clinicians and
cutting edge metabolic imaging experts in Germany with the goal to improve our
understanding of the brain in metabolic diseases. Prof. Dr. Michael Stumvoll and
Prof. Dr. Matthias Blüher from our Department participate on the ICEMED's
projects. Further information |
International Research Project MetaCardis
|
In this project, a consortium of 14 research institutions and companies in
France, Germany, England, Denmark, Sweden and Belgium investigate how the human
intestinal microbiome relates to the development of cardiovascular and metabolic
diseases. Further information |
Diabetes Studies of the German Center for Diabetes Research (DZD) |
The Diabetes Studies of the German Center for Diabetes Research (DZD) combine
basic science, translational research projects, and clinical trials focussing on
diabetes mellitus. We are a study-center of three DZD studies: the German
Prediabetes Intervention-Study (PLIS), the German Study Gestational Diabetes
(PREG) and the German Diabetes Study (DDS). Further information |
Leipzig Research Center for Civilization Diseases (LIFE) |
The Leipzig Research Center for Civilization
Diseases (LIFE) investigates several civilization diseases including diabetes
mellitus, cardiovascular diseases, depression, and allergies
in a longitudinal cohort comprising of a representative sample of the
Leipzig population. Furthermore, the LIFE Research Center is one of 18 study-centers of the German National Cohort
(NAKO). Further information |
Leptin Treatment Center Leipzig |
The Leptin Treatment Center Leipzig provides
leptin treatment for patients with lipodystrophy as one of only 6 centers in
Europe. Head of the Leptin Treatment
Center Leipzig is Prof. Dr. Michael Stumvoll. Contact details can be found here (currently only in German). MD-LEICSYoung physicians are invited to apply for the new 3-year Clinician Scientist program of Leipzig University funded by the German Research Foundation (DFG). The combined clinical and scientific program focusses on translational research in the field of modern diseases (e.g. metabolism, obesity, diabetes, cardiovascular diseases, cardiometabolic complications, eating disorders). Investigating non-communicable "Modern Diseases" is a central topic of the Faculty of Medicine at Leipzig University. The aim of MD-LEICS is to sustainably promote Clinician Scientists in modern diseases through protected research time (50-75%) and an attractive structured curriculum for interdisciplinary clinical and scientific qualification More information can be found here (currently only in German).
|
The Babybiom studyThe infant´s microbiome plays an important role in health and disease throughout life. The Babybiome-Study aims to characterize the bacterial genetic mechanisms facilitating persistent colonization of an infant´s oral- and gut microbiome, which both are implicated in systemic metabolic disease, to identify unknown pathways by which maternal gestational diabetes influences the infant´s microbiome development. A prospective cohort of pregnant women and their families is recruited at the University Hospital Leipzig and Charité Hospital Berlin. Families receive sampling kits via mail to perform self-sampling of stool and oral swabs of each family member at eight time points from preterm until the newborn´s 1st birthday to investigate the origin and development of the infant´s microbiome and the impact of maternal metabolic disease. Further samples for microbial analysis are collected during birth. Phylogenetic analyses conducted at the Max Planck Institute for Infection Biology Berlin (MPIIB), reconstruct the evolutionary history of the bacterial species within the newborn and family, including the identification of the origin of the species within the sampled family microbiome sites. Analysis of de novo mutation as well as acquisition and deletion of mobile genomic elements allow to assess the genomic changes that facilitated the transmission and establishment of the bacterial species in the infant microbiome development. easyLINKAGE - A graphical user interface for
automated linkage analyses |
easyLINKAGE is a joint project of the Institute of Human Genetics, Charité Virchow Campus Berlin and the Division of Nephrology, Department of Medicine, Neurology, and Dermatology, University Clinic Medical Leipzig. We extended the original easyLINKAGE program by enabling linkage analyses for large-scale SNP data in addition to those of microsatellites. We implemented new modules for Allegro, Merlin, SimWalk, GeneHunter Imprinting, GeneHunter TwoLocus, SuperLink and extended FastSLink by automatic loop breaking and new outputs. We added conditional linkage analyses as well as multipoint simulation studies, and extended error test routines by checking for Mendelian/non-Mendelian genotyping errors and for deviations from Hardy–Weinberg equilibrium. Data can be analyzed in sets of markers, in defined centimorgan intervals and by using different allele frequency algorithms. The outputs consist of genome-wide as well as chromosomal postscript plots of LOD scores, NPL scores, P-values and other parameters. Doctoral research ThesisOur devision encourages medical students to engange in a broad spectrum of research topics. We offer the opportunity to thoroughly investigate a research question based on individual interests. Please send your inquiry regarding doctoral theses to our chief secretariat. University Hospital Leipzig
Department of Endocrinology, Nephrology and Rheumatology
Division of Endocrinology Liebigstraße 20, 04103 Leipzig, Germany Email: silke.fritsch@medizin.uni-leipzig.de
|
